Fig. 5. Transcriptional profiles of LAN5 cells treated with the WBM and WIN site inhibitors.
LAN5 cells were treated with DMSO, compound 19 and OICR-9429 for 24 h. a Venn diagram, showing the overlap of differential genes after compound 19 or OICR-9429 treatment. b The top 10 KEGG enrichment pathways for genes induced and suppressed by compound 19 or OICR-9429. c Heatmap displaying ribosome genes affected by OICR-9429 and compound 19 and their log2-fold change in two groups.