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. 2022 Oct 7;44(4):877–887. doi: 10.1038/s41401-022-00999-z

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 8 — Compound 19 binds to the WBM site of WDR5 and hinders the interaction of WDR5 with its ligand, thus regulating the transcription of genes which are related to ribosomes, cell cycle, DNA replication and apoptosis. Through combining with the WIN site inhibitor, OICR-9492, the anti-tumor effect of WDR5 inhibitors is boosted, providing a potential therapeutic avenue for treating neuroblastoma.