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. 2023 Mar 27;14:1709. doi: 10.1038/s41467-023-37256-8

Fig. 7. shAJSZ enhances MGT’s ability to improve heart function post-MI.

Fig. 7

a Schematic depicting the experimental strategy to test the role of AJSZ on heart function post-MI. b, d, f Quantification of scar area (b), fibrosis (d), and cardiac content (f) in PBS, MGT, and MGT + shAJSZ conditions 4 weeks after MI. n = 4 per condition. c, e, g Representative histological heart sections after Masson trichrome staining (scar area) Scale bar: 1.5 mm (c), Col1 (fibrosis) (e), and Tnnt2 (cardiac content) (g) staining in PBS, MGT, or MGT + shAJSZ conditions. DAPI is shown in blue. h Ejection fraction (EF) and i fractional shortening (FS) of the left ventricle were serially quantified by echocardiography in mice injected with PBS, MGT, and MGT + shAJSZ 4 weeks after MI. Cardiac function was improved with MGT + shAJSZ as compared to PBS or MGT conditions. For EF and FS quantification: PBS-treated mice n = 10, MGT-treated mice n = 13, and MGT + shAJSZ treated mice n = 11. Groups were compared using two-tailed unpaired. Scale bars: 1.5 mm. *P < 0.05, **P < 0.01, and ***P < 0.001. Data in the figure are presented as mean values ± standard deviation.