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. 2023 Mar 14;13:1117326. doi: 10.3389/fonc.2023.1117326

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Copyright © 2023 Waller, Tschanz, Winkler and Pruschy

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ephrin-A1 cleavage is mediated by ADAM17. Cellular supernatants derived from NCI-H358 cells were analyzed for cleaved ephrin-A1 24 hours after (A) TMI-005 (25µM) or (B) MEDI3622 (200nM) treatment by ELISA. (C) rhEphrin-A1 was incubated with rhADAM17 for acellular cleavage. TMI-005 inhibited ADAM17-mediated ephrin-A1 cleavage. Bar graphs represent Ephrin-A1 concentration normalized to total cellular protein amount ± SEM from three independent biological replicates. ***, P < 0.001; ****, P < 0.0001.