Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Graphical abstract: The dual role of ADAM17 on EphA2 signaling. Based on our data, ADAM17 influences EphA2 signaling by two mechanisms: 1) Release of growth factors that act on EphA2 pS897 via the MAPK pathway and thereby activate the non-canonical pathway. 2) Cleavage of GPI-anchored ephrin-A1 to prevent receptor internalization and thereby blocking the canonical signaling pathway. In red: EphA2 S897 phosphorylation.
