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. 2023 Mar 14;13:1077342. doi: 10.3389/fonc.2023.1077342

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Copyright © 2023 Zhong, Shen, Zhou, Yu, Wang, Sun, Wang and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The different expression of ferroptosis and hypoxia regulations between high and low HFRS risk groups. (A, B) The boxplots shows the difference in ferroptosis suppressors mRNA expression between the high- and low-HFRS groups of the TCGA (A) and METABRIC (B) cohorts. (C) The heat map shows the association between Reactome hypoxia-related pathways and HFRS score in TCGA BC samples. (D) The boxplot shows the significant difference in the enrichment score of HALLMARK_CANCER_HYPOXIA between high- and low-HFRS risk groups. (*p< 0.05; **p< 0.01; ***p< 0.001; ****p< 0.0001, n.s., not significant).