TABLE 1.
Comparison of baseline data in different treatment groups for severe IgAN (n = 98).
| Group | P + CTX group | P + MMF group | P Group | Supportive treatment group | P | |
|---|---|---|---|---|---|---|
| (n = 35) | (n = 26) | (n = 20) | (n = 17) | |||
| men, n (%) | 15 (42.90) | 11 (42.30) | 8 (40.00) | 8 (47.10) | 0.98 | |
| Year at biopsy (Y) | 35.5 ± 9.2 | 39.3 ± 13.0 | 36.9 ± 12.4 | 43.2 ± 10.3 | 0.11 | |
| SBP (mmHg) | 134.7 ± 19.1 | 134.4 ± 23.8 | 135.8 ± 34.1 | 134.6 ± 22.7 | 1.00 | |
| DBP (mmHg) | 83.0 ± 14.2 | 80.8 ± 13.2 | 82.0 ± 15.7 | 81.4 ± 12.7 | 0.94 | |
| MAP (mmHg) | 100.2 ± 15.1 | 98.7 ± 16.0 | 99.9 ± 20.3 | 99.1 ± 14.8 | 0.99 | |
| Hematuria, n (%), | 25 (71.40) | 19 (73.10) | 15 (75.00) | 9 (52.90) | 0.44 | |
| HGB (g/L) | 129.57 ± 21.38 | 126.25 ± 17.35 | 122.09 ± 21.70 | 129.06 ± 20.61 | 0.59 | |
| ALT (U/L) | 13.60 (8.50–22.90) | 14.70 (9.88–20.10) | 16.25 (10.80–25.15) | 18.00 (14.00–26.65) | 0.41 | |
| CHO (mmol/L) | 5.42 ± 1.32 | 5.54 ± 0.93 | 5.26 ± 1.32 | 5.58 ± 1.35 | 0.84 | |
| Cys C (mg/L) | 0.91 (0.69–1.29) | 0.95 (0.75–1.29) | 0.99 (0.70–1.13) | 1.13 (0.75–1.33) | 0.62 | |
| SUA (μmol/L) | 403.30 (358.60–488.50) | 413.05 (352.95–523.25) | 441.35 (360.00–555.67) | 504.00 (426.90–552.50) | 0.13 | |
| BUN (mmol/L) | 5.00 (3.75–8.28) | 6.21 (4.81–9.27) | 6.40 (4.31–7.89) | 8.60 (6.19–10.86) | 0.12 | |
| ALB (g/L) | 38.80 (34.00–42.40) | 37.05 (34.63–42.15) | 36.65 (33.20–41.33) | 39.90 (35.10–43.70) | 0.63 | |
| Scr (μmol/L) | 94.00 (64.00–153.00) | 100.00 (87.00–142.25) | 97.00 (76.00–119.50) | 136.00 (88.50–209.50) | 0.17 | |
| PCR (g/g) | 1.71 (0.85–3.02) | 1.35 (0.83–2.00) | 1.17 (0.63–2.71) | 0.84 (0.45–2.88) | 0.49 | |
| 24-UPro (g/d) | 1.49 (1.03–2.92) | 1.79 (0.82–2.52) | 1.25 (0.76–3.37) | 1.14 (0.61–3.39) | 0.47 | |
| eGFR (mL/min/1.73m2) | 75.77 (43.11–116.19) | 64.66 (38.27–86.68) | 70.79 (60.13–98.29) | 42.61 (27.46–80.82) | 0.14 | |
| CKD staging (%) | 0.24 | |||||
| 1 | 16 (45.70) | 6 (23.10) | 5 (25.00) | 3 (17.60) | ||
| 2 | 6 (17.10) | 9 (34.60) | 9 (45.00) | 3 (17.60) | ||
| 3 | 8 (22.90) | 6 (23.10) | 4 (20.00) | 6 (35.30) | ||
| 4 | 5 (14.30) | 5 (19.20) | 2 (10.00) | 5 (29.40) | ||
| *Lee’s grades, n (%) | 31(88.60) | 21(80.80) | 17(85.00) | 8(47.10) | 0.01 | |
| M1, n (%) | 19 (54.30) | 15 (57.70) | 13 (65.00) | 5 (29.40) | 0.16 | |
| *S1, n (%) | 35 (100.00) | 26 (100.00) | 20 (100.00) | 13 (76.50) | 0.01 | |
| E1, n (%) | 16 (45.70) | 15 (57.70) | 11 (55.00) | 5 (29.40) | 0.28 | |
| T (1 + 2), n (%) | 28 (80.00) | 23 (88.50) | 17 (85.00) | 16 (94.10) | 0.63 | |
*Comparison among four groups, p < 0.05.