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. 2023 Mar 14;14:1129771. doi: 10.3389/fimmu.2023.1129771

Figure 3.

Figure 3

Investigation of bioengineered OMVs for BCa treatment in vivo. (A) The diagrammatic sketch of experimental design for evaluating BCa inhibition effectiveness of bioengineered OMVs using subcutaneous tumor-bearing mice. (B) Fluorescence images of tumor slice after intratumoral injection of PBS and OMVMPI-C solutions. Cell nuclei were stained with DAPI (blue). Scale bar = 50 μm. Subcutaneous tumor volumes (C) and body weights (D) of tumor-bearing mice recorded every other day from day 0 to day 15 (n = 5). Image (E) and corresponding weights (F) of tumors harvested from tumor-bearing mice at the end of the treatments (n = 5). H&E staining (G) and fluorescence TUNEL staining images (H) of tumor tissue at the end of the treatments. Scale bars = 50 μm. Data in (C, D, F) are presented as mean ± SD. Statistical significance was calculated via one-way ANOVA with a Tukey’s post-hoc test. *p < 0.05, **p < 0.01.