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. 2023 Mar 14;14:1130288. doi: 10.3389/fimmu.2023.1130288

Figure 4.

Figure 4

Treatment of healthy neutrophils with platelet releasate from COVID-19 patients and disease controls. (A) Myeloperoxidase-deoxy ribonucleic acid (MPO-DNA) complexes were quantified from COVID-19 patient and disease control platelet releasate treated neutrophils, measured with a capture ELISA. Data presented as optical density standardized to negative control. *, p<0.05.(B) Heatmap with hierarchical clustering displaying transcriptomic changes between treatment with platelet releasate from COVID-19 patients and disease controls. Bulk RNA sequencing results of gene changes requiring a fold change >2 and p-value <.05. There are 5 upregulated genes and 32 downregulated genes. N = 5. (C) Heatmap and (D) plot displaying the gene set enrichment pathway analysis of complement activation (Enrichment score=-0.493, p=0.038). N = 5.