Table 1.
Characteristics of plasma donors.
| Characteristic | Disease controls (n=12) |
COVID-19 patients (n=14) |
|
|---|---|---|---|
| Age (yrs) | 57 (19) | 60 (8) | |
| Sex (n) | Female | 6 | 5 |
| Male | 6 | 8 | |
| Race (n) | Asian | 1 | 3 |
| Black/African American | 3 | 1 | |
| Native American or Alaskan | 1 | 0 | |
| Unknown/Not reported/Other | 1 | 2 | |
| White | 6 | 7 | |
| Ethnicity (n) | Not Hispanic/Latino | 9 | 6 |
| Hispanic/Latino | 3 | 7 | |
| BMI (mg/kg2) | 21.25 (6.93) | 28.85 (30.77) | |
| Platelet Count (x109/L) | 276 (145) | 221 (115) | |
| Leukocyte Count (x109/L) | 6.45 (3.18) | 8.2 (3.3) | |
| Hemoglobin (g/dL) | 13.65 (2.23) | 13.8 (2.9) | |
| Hospital Days | 7 (7.75) | 8 (12) | |
| ICU Days | 0 (0.5) | 0 (1) | |
| Intubated on Day 1 (n) | No | 11 | 11 |
| Yes | 1 | 2 | |
| Vital Status at Discharge (n) | Alive | 12 | 12 |
| Dead | 0 | 1 | |
| Maximum O2 Requirement on Day 1 (L/minute) | 0 (0-15) | 4 (0-40) | |
| Ventilator Days | 0 (0) | 0 (0) | |
| Admission Acuity (n) | ED only | 1 | 0 |
| Floor | 6 | 8 | |
| Floor, then ICU | 1 | 2 | |
| ED to ICU | 3 | 3 | |
| Unknown | 1 | 0 | |
| TEG Reaction Time (minutes) | 6.5 (0.7) | 6.7 (0.6) | |
| TEG Maximum Amplitude (mm) | 66.9 (6.3) | 67.8 (3.7) | |
| TEG Functional Fibrinogen Maximum Amplitude (mm) | 23.4 (13.3) | 35.45 (12.23) | |
| TEG Lysis (%) | 0.2 (0.6) | 0.3 (0.7) | |
| Aggregometry Baseline Impedance (Resistance Units) | 1363 (106) | 1400 (59) | |
| Aggregometry ADP AUC (Units) | 40 (41) | 67.5 (62.3) | |
| Aggregometry Collagen AUC (units) | 72 (44.8) | 101 (52.8) | |
| Aggregometry Thrombin Analog AUC (units) | 86.5 (60) | 105 (26) | |
| Aggregometry Arachidonic Acid AUC (units) | 42 (40.5) | 56.5 (65.75) | |
| Aggregometry Ristocetin AUC (units) | 56 (48) | 81 (77) | |
| PAI-1 (pg/mL) | 2.5 (1.4) | 4.5 (7.7) | |
| Antiplasmin (% Activity) | 65.7 (24.6) | 72 (29) | |
| Fibrinogen (mg/dL) | 355 (124) | 477.5 (190) | |
| D-dimer (μg/dL) | 1 (3) | 1.2 (0.8) | |
| Factor VIII (% Activity) | 236 (288.3) | 181.5 (117) | |
| vWF (% Activity) | 332 (282.6) | 281 (227) | |
| VEGF (pg/mL) | 15.8 (12.3) | 25.2 (17.4) | |
| Thrombomodulin (pg/mL) | 6252 (2449) | 4871 (2450) | |
| Plasminogen (% Activity) | 110 (36) | 120.5 (48.8) | |
| Protein C (% Activity) | 65.7 (24.6) | 72 (29.12) | |
| P-selectin (pg/mL) | 27.4 (25.8) | 30.4 (24.8) | |
| tPA (pg/mL) | 3081.4 (3007.1) | 2342 (1621) | |
| IL-8 (pg/mL) | 13.21 (11.1) | 14.5 (8.7) | |
| TNFR1 (pg/mL) | 1091.4 (575.1) | 1413.7 (771.9) | |
| Ang1 (pg/mL) | 5481.1 (8740.3) | 6372 (7815) | |
| Ang2 (pg/mL) | 1657.3 (1245.6) | 1013.3 (805.6) | |
| MMP8 (pg/mL) | 2854.4 (3442.3) | 3032.1 (4079) | |
| SPD (pg/mL) | 5286 (4140) | 2723 (2965) | |
| TREM1 (pg/mL) | 215.3 (144.1) | 219.8 (90.3) | |
| IL-18 (pg/mL) | 234.5 (207.1) | 366.4 (146.4) | |
| Cell-free Hgb (pg/mL) | 72.8 (286.4) | 41.21 (148.23) | |
| IP10 (pg/mL) | 77.5 (188.5) | 450 (424.2) | |
| IL-10 (pg/mL) | 6.7 (4.1) | 13.6 (12) | |
| RAGE (pg/mL) | 720.4 (840.5) | 3091.6 (3230.9) |
Data are reported as median (interquartile range), or in the case of maximum O2 requirement, median (minimum-maximum). yrs, years; BMI, body mass index; ED, emergency department; ICU, intensive care unit; TEG, thromboelastography; ADP, adenosine diphosphate; AUC, area under the curve; PAI-1, plasminogen activator inhibitor 1; vWF, von Willebrand Factor; VEGF, vascular endothelial growth factor; tPA, tissue plasminogen activator; IL-8, interleukin 8; TNFR1, tumor necrosis factor receptor 1; Ang1, angiopoietin 1; Ang2, angiopoietin 2; MMP8, matrix metalloprotease 8; SPD, surfactant protein D; TREM1, triggering receptor expressed on myeloid cells 1; IL-18, interleukin 18; Hgb, hemoglobin; IP10, interferon-gamma induced protein 10; IL-10, interleukin 10; RAGE, receptor for advanced glycation end products.