FIGURE 2.

Control of autoimmune hepatitis (AIH) disease activity under standard and non–standard of care. (A) Comparison of serological markers of disease activity [alanine aminotransferase (ALT) at the time of biopsy and modified hepatitis activity index (mHAI) and size of liver infiltrates as histological parameters between AIH patients with standard of care therapies (SOC) and AIH patients with non–standard of care (non-SOC) according to the treatment response (biochemical remission, BR, incomplete response, IR]. (B) The density of liver infiltration with CD4⁺ and CD8⁺ T cells, CD79a⁺ B cells, and CD4⁺FOXP3⁺ regulatory T cells (Treg) and cell ratios of Treg to T and B cells (C). (Horizontal lines represent median and error bars represent the interquartile range; p≥0.05; *p<0.05; **p<0.01; ***p<0.001.) Abbreviations: n.s., not significant; ULN, upper limit of normal.