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Common adverse events
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | % Grade 3‐4 | |
|---|---|---|---|---|---|
| Neutropenia | 2 | 7 | 17 | 16 | 69 |
| Anemia | 20 | 5 | 2 | 0 | 4 |
| Thrombocytopenia | 7 | 2 | 0 | 0 | 0 |
| AST elevation | 5 | 2 | 2 | 1 | 6 |
| ALT elevation | 7 | 3 | 1 | 1 | 4 |
| Hyponatremia | 19 | ― | 6 | 0 | 13 |
| Hypoalbuminemia | 11 | 19 | 3 | 0 | 6 |
| Malaise | 22 | 3 | 0 | 0 | 0 |
| Fatigue | 9 | 3 | 1 | 0 | 2 |
| Anorexia | 12 | 20 | 3 | 0 | 6 |
| Nausea | 17 | 4 | 1 | 0 | 2 |
| Diarrhea | 9 | 10 | 9 | 0 | 19 |
| Peripheral sensory neuropathy | 13 | 1 | 0 | 0 | 0 |
| Febrile neutropenia | ― | ― | 6 | 0 | 13 |
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase.
