1. Summary of methodological quality.

Name of study	Allocat'n generation	Allocat'n concealed	Blinding	Loss to follow up	Attrition rate	Certainty of AD	Comparable severity
ASM981C2315 2005	Unclear	Unclear	Adequate	Adequate	15.36%	Unclear	Adequate
ASM981C2316 2005	Unclear	Unclear	Adequate	Adequate	18.42%	Unclear	Unclear
ASM981C2322 2005	Unclear	Unclear	Adequate	Adequate	10.12%	Unclear	Unclear
ASM981C2402 2005	Unclear	Unclear	Adequate	Inadequate	23.29%	Unclear	Unclear
Barba 2003	Unclear	Unclear	Adequate	Adequate	7.55%	Unclear	Unclear
CASM981C1301 2005	Unclear	Unclear	Adequate	Adequate	13.75%	Adequate	Unclear
CASM981C1303 2005	Unclear	Unclear	Adequate	Adequate	15.61%	Unclear	Unclear
CASM981C2413 2006	Unclear	Unclear	Adequate	Inadequate	27.24%	Unclear	Unclear
CASM981C2436 2006	Unclear	Unclear	Adequate	Inadequate	16.87%	Adequate	Unclear
CASM981C2442 2006	Unclear	Unclear	Adequate	Inadequate	43.5%	Adequate	Unclear
CASM981CDE10 2005	Unclear	Unclear	Adequate	Adequate	15.76%	Adequate	Unclear
CASM981CUS03 2005	Unclear	Unclear	Adequate	Adequate	26.89%	Unclear	Unclear
Eichenfield (a) 2002	Unclear	Unclear	Adequate	Adequate	18.18%	Adequate	Adequate
Eichenfield (b) 2002	Unclear	Unclear	Adequate	Adequate	13.66%	Adequate	Adequate
Ho 2003	Unclear	Unclear	Adequate	Inadequate	23.66%	Adequate	Adequate
Kapp 2002	Unclear	Unclear	Adequate	Inadequate	27.09%	Adequate	Adequate
Kaufmann 2006	Adequate	Unclear	Adequate	Adequate	5.56%	Unclear	Adequate
Kempers 2004	Adequate	Adequate	Adequate	Adequate	11.35%	Unclear	Adequate
Leo 2004	Unclear	Unclear	Adequate	Adequate	0.00%	Adequate	Unclear
Ling 2005	Unclear	Unclear	Adequate	Adequate	16.33%	Adequate	Unclear
Luger 2001	Unclear	Unclear	Adequate	Inadequate	22.31%	Adequate	Adequate
Luger 2004	Adequate	Unclear	Adequate	Inadequate	41.19%	Adequate	Adequate
Meurer 2002	Unclear	Unclear	Adequate	Inadequate	30.21%	Adequate	Adequate
Paller (a) 2005	Adequate	Adequate	Adequate	Adequate	24.18%	Adequate	Adequate
Paller (b) 2005	Adequate	Adequate	Adequate	Inadequate	34.96%	Adequate	Adequate
Paller (c) 2005	Adequate	Adequate	Adequate	Inadequate	21.79%	Adequate	Adequate
Staab 2005	Unclear	Unclear	Adequate	Adequate	19.39%	Adequate	Adequate
Seigfried 2006	Unclear	Unclear	Adequate	Inadequate	21.45%	Adequate	Unclear
Thaci 2003	Unclear	Unclear	Adequate	Inadequate	28.72%	Unclear	Adequate
Wahn 2002	Adequate	Unclear	Adequate	Inadequate	38.26%	Adequate	Adequate
Whalley 2002	Unclear	Unclear	Adequate	Inadequate	36.10%	Adequate	Unclear