Figure 1.

(A) Schematic representation of an amyloid formation pathway. The catalyst of this process might be denaturation, overexpression, or cleavage of a normally folded protein, as well as production of an intrinsically disordered protein.² Figure prepared with icons sourced from ref (3). (B) Examples of structural models of amyloid protofilaments of different origins (transthyretin, insulin, amyloid-β peptide, and α-synuclein), exhibiting the characteristic β-strand composition. (4). Copyright 1996 Elsevier. Adapted with permission from ref (4).