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Simulations of a low permeability, low partitioning drug (terbutaline) using the PermQ model (Korzekwa et al., 2022a). All drug elimination was modeled from either the liver or from a muscle/skin lumped compartment. (A) Varying fum with hepatic elimination, (B) Varying Papp with hepatic elimination, (C) Varying fum with elimination from a muscle/skin lumped compartment, and (D) Varying Papp with elimination from a muscle/skin lumped compartment.
