Fig. 8.
Simulations of a high permeability, high partitioning drug (verapamil) using the PermQ model (Korzekwa et al., 2022a). All drug elimination was modeled from either the liver or from a muscle/skin lumped compartment. (A) Varying fum with hepatic elimination, (B) Varying Papp with hepatic elimination, (C) Varying fum with elimination from a muscle/skin lumped compartment, and (D) Varying Papp with elimination from a muscle/skin lumped compartment Decreasing clearance was necessary for (C) and (D) due to low blood flow.