Table 3.
Third dose adverse vaccine symptoms by brand and age
| 30–50 |
70+ |
|||||
|---|---|---|---|---|---|---|
| BNT162b2 | mRNA-1273 | p | BNT162b2 | mRNA-1273 | pa | |
| n (%)b | 97 | 149 | 493 | 252 | ||
| Completed ≥1 diary | 79 (81.4) | 121 (81.2) | 0.99 | 366 (74.2) | 187 (74.2) | 0.99 |
| Redness near injection site | 11 (13.9) | 25 (20.7) | 0.31 | 48 (13.1) | 45 (24.1) | 0.0017 |
| Swelling near injection site | 13 (16.5) | 41 (33.9) | 0.011 | 48 (13.1) | 57 (30.5) | <0.0001 |
| Hives (not at injection site) | 2 (2.5) | 9 (7.4) | 0.24 | 21 (5.7) | 12 (6.4) | 0.90 |
| Pain near injection site | 76 (96.2) | 117 (96.7) | 0.99 | 280 (76.5) | 169 (90.4) | 0.00013 |
| Any malaise | 47 (59.5) | 92 (76.0) | 0.020 | 130 (35.5) | 99 (52.9) | 0.00012 |
| Any headaches | 55 (69.6) | 78 (64.5) | 0.55 | 110 (30.1) | 88 (47.1) | 0.00012 |
| Any fatigue | 64 (81.0) | 103 (85.1) | 0.57 | 201 (54.9) | 118 (63.1) | 0.080 |
| Any chills | 18 (22.8) | 42 (34.7) | 0.10 | 60 (16.4) | 55 (29.4) | 0.00054 |
| Any muscle aches or pains | 44 (55.7) | 79 (65.3) | 0.22 | 144 (39.3) | 103 (55.1) | 0.00060 |
| Any joint aches or pains | 23 (29.1) | 43 (35.5) | 0.43 | 76 (20.8) | 70 (37.4) | <0.0001 |
| Any nausea | 21 (26.6) | 36 (29.8) | 0.75 | 40 (10.9) | 31 (16.6) | 0.081 |
| Any fevers | 8 (10.1) | 16 (13.2) | 0.66 | 15 (4.1) | 15 (8.0) | 0.084 |
| Other serious problem related to the vaccine | 17 (21.5) | 15 (12.4) | 0.13 | 23 (6.3) | 17 (9.1) | 0.30 |
| ≥1 moderate or severe symptom | 42 (53.2) | 91 (75.2) | 0.0021 | 110 (30.1) | 96 (51.3) | <0.0001 |
a
p values are from chi-square test.
b
The n (%) are the proportions of those completing the diary who reported each of the symptoms.