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. 2022 Dec 22;227(6):780–787. doi: 10.1093/infdis/jiac492

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© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 4. — Functional evolution of anti-SARS-CoV-2 IgG in recipients of the BNT162b2 SARS-CoV-2 mRNA vaccine. A, Resistance of the OD₄₅₀ signal against urea treatment in subsets of sera from vaccine recipients at week 3 (n = 9) and week 25 (n = 8) postvaccination, matched by total anti-spike IgG titers. B, Avidity index of antibodies present in week 3 (n = 9) and week 25 (n = 8) vaccinees in comparison with convalescent individuals. C, Relative inhibition potency of week 25 vaccinee sera (n = 8) towards SARS-CoV-2 variants plotted against that of convalescent individuals. Sera from early (month 2) and late convalescence (month 10) were regrouped into low-avidity (below the 50th percentile) and high-avidity (50th percentile and above) sera based on rank, from bottom to top, in their degree of antibody maturation. *P < .05, **P < .01, ***P < .001, ****P < .0001. Abbreviations: IgG, immunoglobulin G; OD₄₅₀, optical density at 450 nm; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WT, wild type.