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. Author manuscript; available in PMC: 2023 Mar 28.
Published in final edited form as: J Am Chem Soc. 2019 Sep 13;141(38):15013–15017. doi: 10.1021/jacs.9b08273

Scheme 2.

Scheme 2.

Ring-Opening of the Cyclotriphosphate Can Lead to Linearization with the Nucleophile Residing in the Terminal Position (Top, Observed) or the α-Position (Bottom, Not Observed), or Branching (Middle, Not Observed)