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. 2023 Mar 27;11:48. doi: 10.1186/s40337-023-00773-4

Table 4.

Results of the mixed model repeated measures analyses for assessments of eating disorder, major depressive, state-trait anxiety symptoms and quality of life using linear time weighted by the number of days between admission and 6-month follow-up

Symptom Estimate SE df t Sig (p) 95% CI (Lower–Upper)
EDE-Q global score
Intercept 1.633 0.570 679 2.864 .004 0.514 2.752
Time 1 (ADM-FU) 1.374 0.130 679 10.558  ≤ .001 1.118 1.630
Time 2 (DC-FU)  − .0321 0.135 679  − 2.385 .017  − 0.585  − 0.057
AN-BP 0.636 0.439 679 1.449 .148  − 0.226 1.499
AN-R 0.474 0.446 679 1.062 .288  − 0.402 1.350
BN 0.429 0.423 679 1.016 .310  − 0.400 1.259
OSFED 0.589 0.416 679 1.417 .157  − 0.227 1.406
Age at admission  − 0.002 0.007 679  − 0.280 .779  − 0.015 0.011
Admit BMI 0.025 0.009 679 2.699 .007 0.007 0.043
Age of ED onset  − 0.186 0.099 679  − 1.880 .061  − 0.380 0.089
LGBTQ  − 0.199 0.147 679  − 1.360 .174  − 0.487 0.089
PTSD 1.063 0.324 679 3.284  ≤ .001 0.427 1.698
PTSD × Time 1 0.001 0.003 679 0.224 .823  − 0.005 0.006
PTSD × Time 2  − 0.001 0.001 679  − 1.225 .221  − 0.004 0.001
EDI-2 total score
Intercept 35.556 16.366 667 2.173 .030 3.422 67.692
Time 1 (ADM-FU) 27.347 3.737 667 7.317  ≤ .001 20.009 34.685
Time 2 (DC-FU)  − 4.647 3.865 667  − 1.202 .230  − 12.236 2.943
AN-BP 22.728 12.613 667 1.802 .072  − 2.037 47.494
AN-R 19.833 12.775 667 1.552 .121  − 5.251 44.917
BN 17.547 12.092 667 1.451 .147  − 6.196 41.290
OSFED 16.436 11.886 667 1.383 .167  − 6.903 39.774
Age at admission 0.101 0.198 667 0.512 .609  − 0.287 0.490
Admit BMI 0.872 0.268 667 3.251  ≤ .001 0.345 1.398
Age of ED onset  − 7.774 2.840 667  − 2.737 .006  − 13.351  − 2.198
LGBTQ  − 2.670 4.203 667  − 0.635 .525  − 10.924 5.583
PTSD 42.736 9.308 667 4.591  ≤ .001 24.460 61.013
PTSD × time 1  − 0.154 0.083 667  − 1.846 .065  − 0.318 0.010
PTSD × time 2  − 0.025 0.033 667  − 0.766 .444  − 0.090 0.040
PHQ-9
Intercept 5.967 2.538 670 2.351 .019 0.984 10.949
Time 1 (ADM-FU) 5.081 0.578 670 8.788  ≤ .001 3.946 6.216
Time 2 (DC-FU) -2.629 0.599 670  − 4.389  ≤ .001  − 3.806  − 1.453
AN-BP 3.566 1.954 670 1.825 .069  − 0.271 7.403
AN-R 3.399 1.980 670 1.717 .086  − 0.488 7.286
BN 2.917 1.873 670 1.557 .120  − 0.761 6.595
OSFED 3.519 1.841 670 1.911 .056  − 0.096 7.134
Age at admission  − 0.009 0.030 670  − 0.304 .762  − 0.069 0.051
Admit BMI 0.074 0.041 670 1.792 .074  − 0.007 0.156
Age of ED onset  − 0.918 0.439 670  − 2.092 .037  − 1.779  − 0.056
LGBTQ 0.396 0.648 670 0.611 .541  − 0.876 1.667
PTSD 5.404 1.434 670 3.768  ≤ .001 2.588 8.220
PTSD × time 1 0.002 0.013 670 0.172 .863  − 0.023 0.028
PTSD × time 2  − 0.005 0.005 670  − 0.969 .333  − 0.015 0.005
STAI-state anxiety
Intercept 46.821 5.409 665 8.657  ≤ .001 36.201 57.441
Time 1 (ADM-FU) 8.866 1.237 665 7.167  ≤ .001 6.437 11.295
Time 2 (DC-FU)  − 1.621 1.280 665  − 1.266 .206  − 4.135 0.893
AN-BP 1.340 4.166 665 0.322 .748  − 6.840 9.520
AN-R 1.298 4.218 665 0.308 .758  − 6.985 9.581
BN 0.288 3.992 665 0.072 .943  − 7.551 8.127
OSFED 0.012 3.924 665 0.003 .998  − 7.694 7.718
Age at admission 0.005 0.065 665 0.073 .942  − 0.123 0.133
Admit BMI 0.096 0.089 665 1.084 .279  − 0.078 0.270
Age of ED onset  − 1.077 0.935 665  − 1.152 .250  − 2.913 0.759
LGBTQ 0.433 1.394 665 0.311 .756  − 2.304 3.170
PTSD 9.445 3.073 665 3.073 .002 3.410 15.479
PTSD × time 1  − 0.012 0.028 665  − 0.433 .665  − 0.066 0.042
PTSD × time 2 0.001 0.011 665 0.093 .926  − 0.020 0.022
STAI-trait anxiety
Intercept 48.973 4.804 667 10.194  ≤ .001 39.541 58.406
Time 1 (ADM-FU) 6.431 1.097 667 5.861  ≤ .001 4.276 8.584
Time 2 (DC-FU)  − 1.691 1.137 667  − 1.487 .138  − 3.924 0.542
AN-BP 2.252 3.700 667 0.609 .543  − 5.014 9.518
AN-R 2.928 3.747 667 0.781 .435  − 4.430 10.286
BN 1.968 3.546 667 .555 .579  − 4.995 8.932
OSFED 1.0450 3.485 667 .300 .764  − 5.799 7.889
Age at admission  − 0.058 0.058 667  − 1.003 .316  − 0.171 0.055
Admit BMI 0.157 0.079 667 2.000 .046 0.003 0.311
Age of ED onset  − 1.843 0.831 667  − 2.220 .027  − 3.474  − 0.213
LGBTQ 1.056 1.233 667 .857 .392  − 1.365 3.477
PTSD 10.827 2.723 667 3.977  ≤ .001 5.481 16.173
PTSD × time 1  − 0.004 0.024 667  − .167 .867  − 0.052 0.044
PTSD × time 2  − 0.011 0.010 667  − 1.181 .238  − 0.030 0.008
EDQOL total score
Intercept 1.205 0.286 664 4.210  ≤ .001 0.643 1.767
Time 1 (ADM-FU) 0.673 0.066 664 10.357  ≤ .001 0.546 0.801
Time 2 (DC-FU) 0.038 0.067 664 0.568 .571  − 0.094 0.170
AN-BP 0.0179 0.219 664 0.081 .935  − 0.413 0.449
AN-R  − 0.094 0.223 664  − 0.421 .674  − 0.531 0.343
BN  − 0.065 0.210 664  − 0.311 .756  − 0.478 0.347
OSFED  − 0.098 0.207 664  − 0.474 .636  − 0.504 0.308
Age at admission  − 0.003 0.003 664  − 0.952 .341  − 0.010 0.003
Admit BMI 0.012 0.005 664 2.482 .013 0.002 0.021
Age of ED onset  − 0.010 0.049 664  − 2.007 .045  − 0.196  − 0.002
LGBTQ 0.011 0.073 664 0.147 .883  − 0.132 0.153
PTSD 0.765 0.162 664 4.722  ≤ .001 0.447 1.084
PTSD × time 1  − 0.001 0.001 664  − 0.813 .416  − 0.004 0.002
PTSD × time 2  − 0.001 0.001 664  − 1.753 .080  − 0.002 0.0001

All statistically significant comparisons are in bold print for emphasis

AN-BP Anorexia nervosa, binge-purge type, AN-R Anorexia nervosa, restricting subtype, BN Bulimia nervosa, OSFED Other specified feeding and eating disorder, BMI Body mass index, ED Eating disorder, LGBTQ + Lesbian, gay, bisexual, trans, queer, plus, ADM Admission, DC Discharge, FU 6-month follow-up, EDE-Q Eating Disorder Examination—Questionnaire, EDI-2 Eating Disorders Inventory—2, PHQ-9 Patient Health Questionnaire—9, STAI-S Spielberger State-Trait Anxiety Inventory— State Scale, STAI-T Spielberger State-Trait Anxiety Inventory—Trait Scale, EDQOL Eating Disorder Quality of Life, PTSD posttraumatic stress disorder