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. 2023 Mar 28;43:22. doi: 10.1186/s41232-023-00271-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Schematic representation of the skin under H₂ treatment and normal conditions during the early stage wound healing. In addition to anti-inflammation (especially for Th1- and Th17-related systemic inflammation), H₂ treatment brings multiple other benefits (shown in the figure) including faster epidermis thickening, earlier proliferation (red nuclei) of epidermal stem cells (basal cells and hair follicle cells), early differentiation of basal cells in the wound edge (differentiate towards α-SMA⁺ cell type), earlier and better ECM deposit, faster blood vessel formation, mitochondrial damage repair, and moist healing process (less blood scab formation)