Abbreviation/Term	Definition
AIDA	Antibody–antigen interaction-dependent apoptosis
Abd technology	Antibody-derived compound technology
Affimer	Small non-antibody proteins that bind antigens
Biodegrader	An intracellular antibody engineered as a fusion with an E3 ligase for targeted protein degradation of a target protein
CDR	Antibody-complementarity-determining regions
CPPs	Cell-penetrating peptides
CP3	Caspase 3
DARPins	Designed ankyrin repeat proteins
EBV	Epstein–Barr virus
epitope	Antigen-binding amino acids that interact with antibody paratope
Rule of 5	Empirical rules for parameters of drug-like properties of compounds. See [53]
H and L chain	Antibody heavy and light chains
HIV	Human immunodeficiency virus
iDAb	Intracellular domain antibody
IgG	Immunoglobulin G-class antibody
LNP	Lipid nanoparticle
macrodrug	An intracellular antibody used as a drug per se
monobody	Synthetic proteins based on fibronectin type III domain
nanobody	Camelid VHH fragments
NLS	Nuclear localisation signal
paratope	Antibody-binding amino acids that interact with antigenic epitope
PPI	Protein–protein interaction
PROTAC	Proteolysis-targeting chimeric
scFv	Single-chain fragment variable
SIT technology	Suicide (or silencing) intrabody technology
V region	Antibody variable region
VNAR	Shark heavy-chain V region
warhead	Generic term for effector region fused to intracellular antibodies instead of the Fc region of immunoglobulin