Table 1.
Reported repressors or enhancers of CLDN5 promoter
| Transcriptional factors | Ref |
|---|---|
| Enhancers | |
| E26 transformation specific (ETS)-1 | [31, 93] |
| ETS-related gene (ERG) | [29] |
| Sex-determining region Y-box 18 (SOX-18) | [28] |
| Kruppel-like factor 4 | [30] |
| CCAAT/enhancer-binding protein-α (C/EBP-α) | [52] |
| Glucocorticoid receptor | [38] |
| Estrogen receptor β/Sp1 | [39, 40] |
| Vitamin D response element | [41] |
| Repressors | |
| NF-κB subunit p65 (RelA) | [46] |
| SMAD2/SMAD3/SMAD4/β-catenin | [90] |
| Runt-related transcription factors 1 (RUNX1) | [47] |
| ZONAB | [121] |
| β-catenin/FoxO1/Tcf4/Suz12/Ezh2/Eed | [57] |
Eed, embryonic ectoderm development; Ezh2, enhancer of zeste homolog 2; FoxO1, forkhead box protein O1; Suz12, suppressor of zeste 12; Tcf4, transcription factor 4; ZONAB, ZO-1-associated nucleic acid binding protein