Table 3.

Agents targeting mesenchymal epithelial transition factor receptor under clinical investigation for the treatment of colorectal cancer and metastatic colorectal cancer

Agent	Targeted molecule	Condition	Study phase	Clinical trial identifier
Savolitinib	MET	mCRC	Phase II	NCT03592641
Tivantinib	MET	mCRC	Phase I/II	NCT01075048
Onartuzumab	MET	CRC	Phase II	NCT01418222
Cabozantinib	MET/RET/VEGFR-2	CRC	Phase I	NCT02008383
		mCRC	Phase I	NCT03798626
		Refractory mCRC	Phase II	NCT03542877
Rilotumumab	HGF	KRAS wild-type mCRC	Phase I/II	NCT00788957

MET: Mesenchymal epithelial transition factor receptor; mCRC: Metastatic colorectal cancer; CRC: Colorectal cancer; VEGFR: Vascular endothelial growth factor receptor; HGF: Hepatocyte growth factor; RET: Rearranged during transfection.