Table 3.

Differentially methylated regions associated with BDR and FeNO.

Chr	Start †	End †	Gene	Relative Position *	N° of CpGs	Coefficient	FDR
Bronchodilator drug response
5	126408755	126409453	C5orf63	Promoter, first exon, and intron	11	−0.024	2.80 × 10−7
11	7597813	7598150	PPFIBP2	Gene body (alternative transcripts)	5	−0.011	9.24 × 10−7
2	238767350	238767779	RAMP1	671 bp upstream	4	−0.022	2.67 × 10−6
6	31650734	31650849	LY6G5C	Gene body (alternative transcripts)	3	−0.023	8.96 × 10−6
Fractional exhaled nitric oxide
19	46998382	46999839	PPP5D1	Third intron	16	−0.004	1.48 × 10−18
8	22560921	22561950	EGR3	10,622 bp upstream	7	−0.005	3.15 × 10−17
15	76016128	76016334	ODF3L1	Promoter and first exon	6	−0.003	6.66 × 10−14
7	27186553	27187559	HOXA6	Promoter and gene body	11	0.005	2.01 × 10−13
7	27183273	27184736	HOXA-AS3	First intron	33	0.004	2.53 × 10−13
7	27170240	27170831	HOXA4	Promoter and first exon	10	−0.006	1.00 × 10−10
19	57742111	57742443	AURKC	Promoter and first exon	10	−0.008	3.95 × 10−10
7	100844059	100844444	MOGAT3	First exon	7	−0.002	4.21 × 10−10
7	27198188	27198428	HOXA7	1857 bp upstream	3	0.005	1.37 × 10−9
12	41581774	41582136	PDZRN4	Promoter and first exon	6	−0.004	1.37 × 10−9
7	79083996	79084165	MAGI2-AS3	Second intron	7	0.003	2.59 × 10−9
9	125137543	125137593	PTGS1	Second intron	3	0.003	7.61 × 10−9

^† Position based on GRCh37/hg19 build. * Relative position to the transcription start sites. Abbreviations. Chr: Chromosome; BDR: bronchodilator drug response; FeNO: fractional exhaled nitric oxide.