Table 2.

Periodontal Tissue Regeneration Materials Used in Periodontal Tissue Regeneration Therapy.

Product Name	Summary	Characteristics
REGROTH® (Active ingredient: Trafermin (genetical recombination), 0.3% basic Fibroblast Growth Factor: FGF-2, Kaken Pharmaceutical Co., LTD., Tokyo, Japan)	An artificially purified basic fibroblast growth factor, which is expected to regenerate lost alveolar bone and periodontal ligament by increasing the proliferation of periodontal tissue cells.	It can regenerate bone, cementum, and periodontal ligament of a tooth that is about to fall out. It has a high ability to regenerate the alveolar bone.
Emdogain® Gel (Straumann, Basel, Switzerland)	A periodontal tissue regeneration material containing enamel matrix protein, which plays a vital role in tooth development. This protein may be useful for periodontal tissue regeneration.	Because of the large number of cases treated, there is a wealth of evidence (e.g., papers) and a relatively high degree of certainty. It is compatible with various bone replacement materials used as bone substitutes and can be easily used in combination with bone replacement materials.
Geistlich Bio-Oss® (Geistlich Pharma AG, Wolhusen, Switzerland)	A bone grafting material, which is expected to promote bone regeneration when applied to bone defects caused by periodontal disease.	It is a natural bovine-derived porous bone filler with excellent osteoconductivity. It promotes growth and provides the bone volume necessary for implant placement in alveolar bone regeneration and augmentation. It is also highly compatible with the human body. It reduces the risk of infection.
Cytrans® Granules (Carbonated apatite granules, GC Corporation, Tokyo, Japan).	A bone grafting material composed primarily of carbonate apatite, which is expected to promote bone regeneration when applied to bone defects caused by periodontal disease.	The main component, carbonate apatite, has the same composition as the bone, so it is efficiently replaced by the patient’s own bone, achieving strong osseointegration while maintaining the target bone surface height.
Cytrans® Elashield (GC Corporation, Tokyo, Japan).	An absorbable membrane prepared from a chemically synthesized heavy polymeric material, which is expected to promote bone regeneration when applied to alveolar bone defects along with bone grafting materials.	The raw material is a fully synthetic polymer with a long absorption period suitable for GBR. It is designed to be easy to use and prevent postoperative gingival fissures because of its moderate firmness, flexibility, and ability to follow the shape of the bone. It can be used not only with autologous bone but also with bone replacement materials such as Cystrans Granules.
Geistlich Bio-Gide® (Geistlich Pharma AG, Wolhusen, Switzerland)	An absorbable collagen membrane, which is expected to promote bone regeneration when applied to alveolar bone defects along with bone graft materials.	It has excellent tissue integration and strongly promotes bone regeneration. Due to its natural collagen structure, it is less prone to rupture than other membranes, resulting in fewer problems. The procedure is simple because membrane removal is not required. The burden on the patient is greatly reduced.