Figure 3.

Strontium ranelate reduced orthodontic tooth movement and root resorption in rats. Three-dimensionally reconstructed micro-CT images of orthodontic tooth movement (a) and root resorption at the pressure side of the first molars (b) on days 3, 7, and 14 in different groups after orthodontic movement devices were established in rats. (c) HE staining images of root resorption at the pressure side of the first molars on day 7 in different groups. Quantitative analyses of orthodontic tooth movement (d), root resorption (e), and structure model index, thickness, bone volume/total volume, and trabecular space of the trabecular bone (f) at the pressure side of the first molars on days 3, 7, and 14 in different groups after orthodontic movement devices were established. (n = 5, mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001).