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. 2023 Mar 16;10(3):365. doi: 10.3390/bioengineering10030365

Figure 4.

Figure 4

Strontium ranelate inhibited osteoclast differentiation and the expression of osteoclast markers in rats. (a) TRAP staining images of osteoclasts and immunohistochemical staining images of RANK, OPG, c-Fos, TRAF6, MMP-14, NFATc2, and CTSK at the pressure side of the first molars on day 7 in different groups. (b) Number of osteoclasts and the mean optical density (MOD) of RANK, OPG, c-Fos, TRAF6, MMP-14, NFATc2, and CTSK at the pressure side of the first molars on days 3, 7, and 14 in different groups. (n = 5, mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001).