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. 2023 Mar 11;11(3):855. doi: 10.3390/biomedicines11030855

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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mRNA Expression levels of brain tissue from 4 h after CA-CPR. All results were presented as boxplots showing the quartiles, the 5th and 95th percentiles (whiskers), the median (line) and the mean (x). Normalized expression of each group (n = 6) of cytokines (TNF-α, IL-6, IL1β), cell adhesion molecules (ICAM-1, VCAM-1), TLR2, transcription factors (HIF-1α; Nrf2), neuron-specific marker (S100B, ENO2 (NSE)). All expression differences were Kruskal-Wallis tested. IL-6 mRNA expression level was lower in the Pep19-2.5 compared to the control (p = 0.009) as well as the Pep19-4LF group (p = 0.037). The level of ICAM-1 mRNA expression was lower in the Pep19-2.5 than in the control group (p = 0.018).