Table 1.
Global parameters of CA-CPR. The significance levels were calculated using the Kruskal–Wallis test.
| Experimental Groups | ||||
|---|---|---|---|---|
| Intervention: | Ctrl. (NaCl 0,9%) | Pep19-2.5 | Pep19-4LF | |
| n = 37 | n = 34 | n = 37 | ||
| Parameter | Mean ± SD | Mean ± SD | Mean ± SD | p Value |
| Baseline before CA | ||||
| heart rate (1/min) MAP (mm Hg) body temperature (°C) |
210.78 ± 23.81 | 220.71 ± 23.52 | 220.34 ± 25.15 | 0.141 |
| 64.95 ± 8.26 | 68.79 ± 9.03 | 70.32 ± 7.67 | 0.021 * | |
| 36.21 ± 0.28 | 36.06 ± 0.20 | 36.10 ± 0.20 | 0.033 † | |
| CA | ||||
| ROSC time (s) dosage epinephrine (μg) extubation (min) |
63.32 ± 27.74 | 70.76 ± 37.43 | 64.39 ± 43.85 | 0.375 |
| 13.38 ± 3.14 | 14.04 ± 3.84 | 12.89 ± 3.61 | 0.276 | |
| 169.53 ± 17.81 | 171.31 ± 14.22 | 175.06 ± 17.86 | 0.376 | |
| 1 h after CA | ||||
| heart rate (1/min) | 328.56 ± 75.80 | 352.00 ± 88.82 | 337.91 ± 78.92 | 0.763 |
| MAP (mm Hg) | 57.33 ± 8.98 | 56.00 ± 4.86 | 52.67 ± 2.92 | 0.592 |
| body temperature (°C) | 36.25 ± 0.26 | 36.30 ± 0.35 | 36.33 ± 0.27 | 0.379 |
| 2 h after CA | ||||
| heart rate (1/min) | 273.57 ± 71.99 | 298.64 ± 75.87 | 300.11 ± 76.86 | 0.448 |
| MAP (mm Hg) | 57.80 ± 7.52 | 55.00 ± 0.00 | 53.00 ± 2.00 | 0.664 |
| body temperature (°C) | 36.36 ± 0.36 | 36.39 ± 0.34 | 36.44 ± 0.31 | 0.356 |
* In controls, blood pressure before the induced cardiac arrest was lower than in peptide-treated groups. When considered pairwise, blood pressure was significantly higher in Pep19-4LF (p = 0.008), and in Pep19-2.5, the difference did not reach significance (p = 0.054). † Before cardiac arrest induction, body temperature was lower in Pep19-2.5-treated animals, but when considered pairwise, the difference was significant only compared to control animals (p = 0.010), but not compared to Pep19-4LF (p = 0.099).