Proposed sleep–wake interaction of reactive oxygen species (ROS), redoxome, anion carrier mediators, uncoupling and temperature related to cellular processes of endothermic animals in general, but especially related to mitochondrial (Mt) function and the electron transport chain (ETC). Process activity is shown raised or lowered for parameters such as glutathione (GSH), the oxidized form of GSH (GSSG), metabolic pathways, mitochondrial complexes I and II (CI & CII), NADPH:NADP+ agents of nicotinamide adenine dinucleotide phosphate, tricarboxylic acid (TCA) cycle and triiodothyronine (T3).