Scheme 2.
Synthesis of flavanone-derived γ-oxa-ε-lactones (82). Reagents and conditions: (a) KOH/MeOH, reflux, 24–48 h, then HCl (2–3 min), 69–94%; (b) CH3COONa/EtOH, reflux, 48 h, 61–79%; and (c) m-CPBA/CH2Cl2, rt., 48 h, 67–90%.
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