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Synthesis of isoxazole-acridone derivatives (105). Reagents and conditions: (a) [Cu], K2CO3; (b) polyphosphoric acid (PPA), 120 °C; (c) propargyl bromide, K2CO3, tetra-n- butylammonium bromide (TBAB) as catalyst (PTC), DMF, rt. 6 h, 75%; and (d) Method 1: Et3N, chloroform, 50 °C, 6 h; Method 2: Et3N, chloroform, microwave irradiation (200 W), 40–70 °C, 20–25 min, 45–85%.
