Scheme 8.
Synthetic route of N-alkylcarbazole aminothiazoles (117). Reagents and conditions: (a) alkyl bromide, NaH, dry DMF, rt., 6 h, 96–98%; (b) ClCH2COCL, AlCl, dry DCM, rt., 24 h, 30–36%; (c) thiourea, ethanol, reflux, 1 h, 94–96%.
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