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. 2023 Mar 22;12(3):628. doi: 10.3390/antibiotics12030628

Scheme 9.

Scheme 9

Synthesis of novel series of carbazole derivatives (122, 124 and 126). Reagents and conditions: (a) DMC, DABCO, 95 °C, 24 h, or KOH, 25 °C, 2 h, or NaH, DMF, 25 °C, 16 h; (b) POCl3, DMF, 90 °C, 8–18 h; (c) AcOH, 120 °C, 4–8 h, 35.1–61.6%; (d) CH2CH3OH, HCl, 40 °C, 6 h, or CH3OH, AcOH, 68 °C, 4 h, 38.7–64.6%; and (e) CH2CH3OH, AcOH, 70 °C, 5 h, 64.2–80%.