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. 2023 Mar 22;12(3):628. doi: 10.3390/antibiotics12030628

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 11 — Synthesis of a series of novel pyrimidine derivatives containing sulfonate esters. Reagents and conditions: (a) NH₂SNH₂, KOH, EtOH 70 °C, 0.5 h, 85–90%; (b) C₂H₅I, K₂CO₃, DMF, rt.; (c) MeI, K₂CO₃, DMF, rt.; (d) benzyl chloride, K2CO3, DMF, rt.; (e) RSO₂Cl, Et₃N, DCM, rt., 12 h, 40–82%; (f) RSO₂Cl, Et₃N, DCM, rt., 12 h, 65%, 69%; (g) RSO₂Cl, Et₃N, DCM, rt., 12 h, 70%, 75%.