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. 2023 Mar 8;11(3):825. doi: 10.3390/biomedicines11030825

Figure 1.

Figure 1

Features of HIF-1α-overexpressing MSCs (HIF-MSCs). (A). Morphology of MSCs before and after lentiviral transfection. (B). HIF-MSCs had a similar phenotype as MSCs. (C). Relative expression of HIF-1α in P1 and P3 HIF-MSCs at the mRNA and protein levels significantly increased compared to that in MSCs (**** p < 0.0001, ** p < 0.01, * p < 0.05). (D). HIF-MSCs had a similar typical S-type growth curve as MSCs. (E). Viability of MSCs and HIF-MSCs was assessed using CCK-8. HIF-MSCs had an enhanced viability compared to that of MSCs. (**** p < 0.0001, *** p < 0.001). (F). Relative expression of VEGF, GAPHD, LDHA, and CXCR-4 in HIF-MSCs at the mRNA level significantly increased compared to that in MSCs (**** p < 0.0001, * p < 0.05). “ns” represented no significant difference.