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. 2023 Mar 8;11(3):825. doi: 10.3390/biomedicines11030825

Figure 2.

Figure 2

HIF−MSCs attenuate TNBS−induced experimental colitis. (A). Weight curve of mice. (B). Weight loss rate before and after transplantation (*** p < 0.001, * p < 0.05). (C). DAI decreased after HIF−MSC transplantation (**** p < 0.0001, ** p < 0.01). (D). The shortened colon recovered significantly in the HIF−MSC group compared with that in the MSCs group (**** p < 0.0001, * p < 0.05), and the degree of tissue lesion was obviously reduced (E). The pathology score of the HIF-MSC group was significantly decreased compared to those of the TNBS and MSC groups (**** p < 0.0001, *** p < 0.001, * p < 0.05). (F). Typical histopathological performance of colon tissue in each group. (G). Expression of Ki67, eNOS, and occludin in the colon tissue was detected via Western blotting. Expression in the HIF−MSC group was significantly higher than those in the TNBS and MSC groups (**** p < 0.0001, *** p < 0.001, ** p < 0.01, * p < 0.05). “Ns” represented no significant difference.