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. 2023 Mar 14;14:1113194. doi: 10.3389/fimmu.2023.1113194

Table 4.

Computation of Cut-off values using Mean +-2Sd and Mean +-3Sd.

Analysis Antibody # negatives 95% CI Cut Off Point (Se, Sp)
Mean +-2 Standard Deviations S-IgG 205 (-0.192, 0.487) 0.487 (92.45%, 95.12%)
S-IgM 206 (-0.260, 0.739) 0.739 (69.35%, 95.14%)
S-IgA 206 (-0.142, 0.185) 0.185 (100%, 97.09%)
N-IgG 207 (-0.223, 0.874) 0.874 (45.19%, 93.24%)
N-IgM 207 (-0.105, 0.701) 0.701 (3.85%, 95.17%)
N-IgA 207 (-0.109, 0.345) 0.345 (62.16%, 98.07%)
RBD-IgG 203 (-0.143, 0.264) 0.264 (87.06%, 96.55%)
RBD-IgM 203 (-0.233, 0.681) 0.681 (27.27%, 93.60%)
RBD-IgA 203 (-0.022, 0.057) 0.057 (100%, 97.54%)
Analysis Variable Mean ± 3SD Cut-off Point (Se,Sp)
Mean ± 3 Standard Deviations S-IgG 205 (-0.361, 0.656) 0.656 (82.08%, 98.05%)
S-IgM 206 (-0.509, 0.989) 0.989 (51.61%, 98.06%)
S-IgA 206 (-0.224, 0.267) 0.267 (92.16%, 99.03%)
N-IgG 207 (-0.498, 1.149) 1.149 (30.77%, 98.55%)
N-IgA 207 (-0.222, 0.458) 0.458 (48.65%, 98.55%)
RBD-IgG 203 (-0.244, 0.365) 0.365 (72.94%, 98.03%)
RBD-IgM 203 (-0.461, 0.910) 0.910 (12.72%, 97.04%)
RBD-IgA 203 (-0.042, 0.077) 0.077 (100%, 98.03%)

Se, Sensitivity; Sp, Specificity.