Skip to main content
. 2023 Mar 5;12(3):647. doi: 10.3390/antiox12030647

Figure 5.

Figure 5

Effect of AOAA (300 µM) or HMPSNE (200 µM) on cellular bioenergetics in EO771 cells. The CBS/CSE inhibitor AOAA or the 3-MST inhibitor HMPSNE reduced mitochondrial electron transport and aerobic ATP generation when cells utilized glucose as their main substrate (A–D). HMPSNE also reduced glycolytic activity (E–G). Both inhibitors (AOAA or HMPSNE) also reduced mitochondrial function when cells were utilizing glutamine (rather than glucose) as their substrate (via glutaminolysis) (H–J). N = 3 independent experiments ± SEM; * p < 0.05 or ** p < 0.01 shows a significant inhibitory effect of AOAA or HMPSNE.