Table 2.
Survival times of F98 glioma-bearing rats after neutron irradiation.
| Group | n a | Survival Time (Days) | %ILS c | p-Value d | ||
|---|---|---|---|---|---|---|
| Mean ± SD | Median | 95% CI b | ||||
| Untreated | 5 | 30.0 ± 4.0 | 30.0 | 26–34 | - | - |
| Neutron only | 4 | 33.0 ± 7.7 | 35.0 | 22–40 | 16.7 | 0.18 |
| BNCT using BPA 2.5 h | 6 | 43.0 ± 3.8 | 42.0 | 39–50 | 40.0 | 0.0011 |
| BNCT using BPA 8 h | 5 | 40.2 ± 5.6 | 40.0 | 34–48 | 33.3 | 0.0079 |
| BNCT using cRGD-MID-AC 2.5 h | 7 | 42.4 ± 8.6 | 43.0 | 32–47 | 43.3 | 0.0033 |
| BNCT using cRGD-MID-AC 8 h | 6 | 50.3 ± 26.8 | 38.5 | 27- | 28.3 | 0.0499 |
a n indicates number of Fischer rats per group. b CI is confidence interval. c Percent increase in life span (%ILS) was defined relative to the mean survival time (MST) of the untreated group. d p-values were calculated using the log-rank test compared to untreated based on the results obtained from the Kaplan–Meier curves in the neutron-irradiation experiment for F98 glioma-bearing rats.