Table 2.

AQP transcript expression levels in cortical regions differ from those in the hippocampal formation. Differential expression analysis of AQPs in the (i) PCx and (ii) TCx as compared with HIP for subjects in the combined C and AC groups. The average expression (AveExpr) was determined by averaging all RNAseq levels over all probes used for the indicated gene. t-values represent the test statistic associated with the comparison of the two means using two-sample t-tests, with positive values indicating a larger average RNAseq in the cortical region compared to the hippocampus. p values were adjusted (Adj P) for multiple tests using the Bonferroni correction, with significant differences indicated as p < 0.05.

(i) PCx	Gene	logFC	AveExpr	t	p Value	adj. p Val
Higher expression
	AQP11	1.2660	−0.1312	6.8948	<0.001	<0.001
Lower expression
	AQP3	−1.8606	0.2854	−13.497	<0.001	<0.001
	AQP1	−1.1530	−0.2480	−8.046	<0.001	<0.001
	AQP4	−0.8933	0.0305	−4.396	<0.001	1 × 10−4
	AQP10	−0.5890	0.2891	−3.164	0.0022	0.0058
	AQP9	−0.5273	0.1916	−2.441	0.017	0.0368
No significant difference
	AQP5	−0.3550	−0.0021	−1.954	0.0544	0.0911
	AQP2	−0.3983	0.2462	−1.940	0.0561	0.0911
	AQP0	−0.2684	0.0776	−1.362	0.1773	0.2561
	AQP8	0.1785	0.2422	1.0513	0.2964	0.3854
	AQP12	0.1078	0.2901	0.3748	0.7088	0.8377
	AQP7	0.0299	0.2040	0.1616	0.8721	0.9448
	AQP6	0.0129	−0.2175	0.0623	0.9505	0.9505
(ii) TCx	Gene	logFC	AveExpr	t	p Value	adj. p Val
Higher expression
	AQP11	0.8442	-0.1312	4.6514	<0.001	<0.001
Lower expression
	AQP3	−1.8251	0.2854	−13.39	<0.001	<0.001
	AQP1	−1.3989	−0.2480	−9.876	<0.001	<0.001
	AQP4	−0.9932	0.0305	−4.945	<0.001	<0.001
	AQP9	−0.6515	0.1916	−3.051	0.0031	0.0082
	AQP10	−0.5451	0.2891	−2.963	0.0041	0.0088
No significant difference
	AQP0	−0.4008	0.0776	−2.057	0.0431	0.0801
	AQP5	−0.3258	−0.0021	−1.814	0.0737	0.1197
	AQP2	−0.3557	0.2462	−1.753	0.0837	0.1208
	AQP12	−0.3756	0.2901	−1.321	0.1904	0.2475
	AQP8	0.1857	0.2422	1.106	0.2721	0.3216
	AQP6	−0.2120	−0.2175	−1.039	0.302	0.3271
	AQP7	−0.0685	0.2040	−0.375	0.7086	0.7086