Table 3.

Ratios of quantified AQP transcript levels in parietal cortex as compared to the hippocampal formation differ with age. The average expression (AveExpr) levels were determined by averaging the RNAseq levels for all probes used for a given gene. t-values represent the test statistic generated by a comparison of the means using two-sample t-tests, with positive values indicating a larger average value for the RNAseq level in the parietal cortex region as compared to the hippocampus. P values were adjusted (Adj P) for multiple tests using the Bonferroni correction, with significant differences indicated by p < 0.05.

(i) C	Gene	logFC	AveExpr	t	p Value	adj. p Val
Higher expression
	AQP11	1.6950	−0.1312	3.9866	1 × 10−4	8 × 10−4
	AQP9	1.2396	0.1916	2.7069	0.0079	0.0257
Lower expression
	AQP3	−1.5951	0.2854	−4.4059	<0.001	3 × 10−3
	AQP10	−1.2611	0.2891	−3.1242	0.0023	0.01
No significant difference
	AQP0	−0.7967	0.0776	−1.6654	0.0988	0.2568
	AQP4	0.6127	0.0305	1.5691	0.1196	0.2591
	AQP7	0.4365	0.2040	1.0265	0.307	0.5701
	AQP2	−0.3546	0.2462	−0.7644	0.4463	0.7253
	AQP6	0.2345	−0.2175	0.5093	0.6116	0.8834
	AQP12	0.1776	0.2901	0.2705	0.7873	0.9189
	AQP8	−0.0834	0.2422	−0.2207	0.8258	0.9189
	AQP5	0.0477	−0.0021	0.1169	0.9072	0.9189
	AQP1	−0.0299	−0.2480	−0.1020	0.9189	0.9189
(ii) AC	Gene	logFC	AveExpr	t	p Value	adj. p Val
Higher expression
	AQP11	1.2161	−0.1312	6.0634	<0.001	<0.001
Lower expression
	AQP3	−1.8470	0.2854	−10.815	<0.001	<0.001
	AQP1	−1.4439	−0.2480	−10.439	<0.001	<0.001
	AQP4	−1.2894	0.0305	−7.0001	<0.001	<0.001
	AQP9	−0.9655	0.1916	−4.4691	<0.001	1 × 10−4
	AQP5	−0.4671	−0.0021	−2.4253	0.017	0.0368
No significant difference
	AQP10	−0.3984	0.2891	−2.0920	0.0388	0.0721
	AQP2	−0.3731	0.2462	−1.7051	0.0911	0.148
	AQP8	0.2499	0.2422	1.4010	0.1641	0.2371
	AQP0	−0.0976	0.0776	−0.4325	0.6663	0.8245
	AQP12	0.1206	0.2901	0.3895	0.6977	0.8245
	AQP7	−0.0571	0.2040	−0.2847	0.7764	0.8411
	AQP6	−0.0128	−0.2175	−0.0587	0.9533	0.9533