Figure 2.

Age-related Lonp1 effects on cardiomyocytes and myocytes. In the mitochondria of cardiomyocytes and myocytes, Lonp1 plays an important role in counteracting ROS production and maintaining mitochondrial homeostasis through efficient mitophagy, DNA repair system, and UPRmt response. During aging, Lonp1 levels decrease, leading to higher ROS levels, impaired mitophagy, release of damaged mtDNA and fragmented dsDNA, and impaired UPRmt response, a series of effects that can favour myocyte damage in skeletal muscle and sarcopenia.