Table 1.

Main physiological functions of Lonp1 in the mitochondria.

Lonp1 Functions	References
Selectively degrades oxidized and damaged proteins, including aconitase	[23]
Maintains normal cell viability in response to acute stress stimuli when upregulated	[24,25]
Works with mitochondrial HSP70 chaperone system to promote protein folding in mitochondria	[27]
Supports incoming proteins folding through its chaperone-like function and degrades abnormal imported proteins	[28]
Contributes to the solubilization of mitochondrial proteins	[28]
Promotes cell proliferation, apoptotic resistance to stresses	[25,29,30]
Involved in the regulation of mitochondrial dynamics and mitophagy	[16]
Implicated in the proteolytic system responsible for PINK1 degradation	[33,34,35]
Can bind mitochondrial DNA	[18]
Involved in the regulation of mitochondrial DNA copy number, through direct and indirect mechanisms	[18,40,41,42,43]