Relationship between AAV2 and HAdV-F in wastewater samples and SAHUE clinical cases in children, Ireland, July 1, 2020–July 30, 2022. Eighty-five 24-h composite wastewater samples collected during July 1, 2020–July 30, 2022, were retroactively analyzed for SARS-CoV-2, AAV2, HAdV-F, and the human biomarker crAss-2. A) Number of probable SAHUE cases and HAdV-F–positive clinical samples reported per week during the study period. B) Daily viral load of HAdV-F, AAV2 VP1, and AAV2 NSP detected in influent of the Ringsend WWTP, Dublin, Ireland. C) Daily viral load of SARS-CoV-2 RNA N1 and DNA extraction crAss_2 control in influent of the Ringsend WWTP. AAV2, adeno-associated virus type 2; GC, genome copies; HAdV-F, human adenovirus types F; N1, nucleocapsid protein 1; NSP, nonstructural protein; SAHUE, severe acute hepatitis of unknown etiology; VP, viral protein; WWTP, wastewater treatment plant.