Table 6.
KEGG pathway enrichment analysis for renal proteins was significantly more carbonylated due to the HFHS-diet intake compared to STD-diet (red), and for renal proteins, the analysis was significantly less carbonylated due to the supplementation of the HFHS diet with FG, fish oil, and both (green) 1.
| ID | KEGG Pathway | Effect of HFHS | Effect of FG | Effect of ω3 | Effect of FG + ω3 |
|---|---|---|---|---|---|
| rno04964 | Proximal tubule bicarbonate reclamation | 6.10 × 10−3 | |||
| rno00910 | Nitrogen metabolism | 4.60 × 10−3 | |||
| rno01230 | Biosynthesis of amino acids | 3.61 × 10−8 | 0.00051 | 5.05 × 10−8 | 1.28 × 10−6 |
| rno00400 | Phenylalanine, tyrosine and tryptophan biosynthesis | ||||
| rno00360 | Phenylalanine metabolism | ||||
| rno00350 | Tyrosine metabolism | ||||
| rno00380 | Tryptophan metabolism | 3.20 × 10−7 | 0.0116 | 0.00083 | |
| rno00280 | Valine, leucine and isoleucine degradation | 8.40 × 10−9 | 0.00028 | 0.0222 | |
| rno00250 | Alanine, aspartate and glutamate metabolism | 0.0114 | 0.0062 | 0.0117 | |
| rno00410 | beta-Alanine metabolism | 1.90 × 10−4 | |||
| rno00260 | Glycine, serine and threonine metabolism | ||||
| rno00330 | Arginine and proline metabolism | 0.00077 | 0.0222 | ||
| rno00220 | Arginine biosynthesis | 8.47 × 10−5 | 0.003 | 0.0056 | |
| rno00270 | Cysteine and methionine metabolism | ||||
| rno00340 | Histidine metabolism | 0.0072 | |||
| rno00310 | Lysine degradation | 4.07 × 10−5 | 0.0258 | ||
| rno01200 | Carbon metabolism | 2.86 × 10−16 | 1.59 × 10−13 | 1.59 × 10−13 | 5.01× 10−13 |
| rno00010 | Glycolysis/Gluconeogenesis | 1.44 × 10−8 | 0.00034 | 0.00034 | 3.51 × 10−5 |
| rno00020 | Citrate cycle (TCA cycle) | 9.20 × 10−3 | 0.0066 | ||
| rno00620 | Pyruvate metabolism | 3.10 × 10−4 | |||
| rno01210 | 2-Oxocarboxylic acid metabolism | 6.91 × 10−5 | 0.0028 | 0.0055 | |
| rno00030 | Pentose phosphate pathway | 0.0092 | 0.0054 | 0.0099 | |
| rno00040 | Pentose and glucuronate interconversions | 9.20 × 10−3 | 0.0054 | 0.0099 | |
| rno00051 | Fructose and mannose metabolism | 0.00026 | 0.0001 | 7.81 × 10−5 | 0.00038 |
| rno00630 | Glyoxylate and dicarboxylate metabolism | 2.10 × 10−4 | 0.0066 | 0.0099 | |
| rno00071 | Fatty acid degradation | 2.04 × 10−5 | 0.00083 | ||
| rno00561 | Glycerolipid metabolism | 5.00 × 10−5 | 0.0174 | 1.50 × 10−3 | |
| rno00650 | Butanoate metabolism | 0.00016 | 0.0086 | ||
| rno00640 | Propanoate metabolism | 0.0099 | 0.0066 | ||
| rno00053 | Ascorbate and aldarate metabolism | 0.0061 | |||
| rno00480 | Glutathione metabolism | ||||
| rno00980 | Metabolism of xenobiotics by cytochrome P450 | ||||
| rno04146 | Peroxisome | 0.0028 | 0.0287 | 0.0263 | 2.80 × 10−3 |
| rno04213 | Longevity regulating pathway—multiple species | 0.0323 | 0.0281 | ||
| rno05418 | Fluid shear stress and atherosclerosis | ||||
| rno04066 | HIF-1 signaling pathway | 5.90 × 10−3 | 0.0465 | 0.0429 | 0.0055 |
1 KEGG pathway enrichment was conducted by using STRING. Only pathways significantly enriched at FDR< 5% are considered. FDR values of each pathway are shown in table. FDR: False Discovery Rate.