Table 1.

Interplay between NO and dopamine levels.

Causal Trigger	Effect
S-Nitrosylation of tyrosine hydroxylase	↑ Dopamine synthesis Indirect increase in dopamine metabolites
Dopamine activation of mtNOS	↑ NO synthesis
↑ Peroxynitrile	↓ Dopamine re-uptake
↑ Glutamate	↑ NO synthesis ↑ Dopamine oxidation
↑ NO ↑ Peroxynitrile	↑ Dopamine oxidation

Abbreviations: mtNOS, mitochondrial nitric oxide synthase; NO, nitric oxide; ↑ increase; ↓ decrease. References: [7,67,81].