Table 3.
Correlation between the circulating levels of free fatty acids and oxylipins and the intrahepatic fat content or malondialdehyde levels.
| IFC (%) |
MDA (nM) |
||
|---|---|---|---|
| AA (nM) |
Cor. | 0.572 | 0.204 |
| Sig. | 0.000 | 0.023 | |
| EPA (nM) |
Cor. | 0.424 | 0.163 |
| Sig. | 0.002 | 0.109 | |
| ETA (nM) |
Cor. | 0.513 | 0.103 |
| Sig. | 0.003 | 0.298 | |
| 15HETE (nM) |
Cor. | 0.442 | 0.345 |
| Sig. | 0.001 | 0.001 | |
| 17DoHE (nM) |
Cor. | 0.488 | 0.140 |
| Sig. | 0.000 | 0.202 | |
| RvD2 (nM) |
Cor. | 0.019 | 0.241 |
| Sig. | 0.897 | 0.024 | |
| MaR1 (nM) |
Cor. | 0.307 | 0.446 |
| Sig. | 0.032 | <0.001 | |
| LXB4 (nM) |
Cor. | 0.289 | 0.197 |
| Sig. | 0.044 | 0.071 | |
| LTB4 (nM) |
Cor. | 0.231 | 0.239 |
| Sig. | 0.110 | 0.028 | |
| 3HMYR (nM) |
Cor. | 0.286 | 0.260 |
| Sig. | 0.046 | 0.005 | |
| 16HPAL (nM) |
Cor. | 0.239 | 0.262 |
| Sig. | 0.050 | 0.013 | |
| 12HEST (nM) |
Cor. | 0.438 | 0.307 |
| Sig. | 0.002 | 0.001 | |
| PGF2α (nM) |
Cor. | 0.241 | 0.227 |
| Sig. | 0.047 | 0.037 | |
| MDA (nM) |
Cor. | 0.222 | - |
| Sig. | 0.023 | - |
Statistical analysis: Bivariate correlation Pearson test. Cor. indicates Pearson correlation coefficient. Sig. indicates statistical significance. Bold number indicates statistically significant p < 0.05. AA: 5,8,11,14-Eicosatetraenoic acid (Arachidonic acid); EPA: 5,8,11,14,17-eicosapentenoic acid; ETA: 8,11,14,17-eicosatetraenoic acid; 15HETE: 15-Hydroxy-5,8,11,13-Eicosatetraenoic acid; 17DoHE: 17-Hydroxy-4,7,10,13,16,19-docosahexaenoic acid; RvD2: 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid (Resolvin D2); MaR1: 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid (Maresin-1); LXB4: (5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxyicosa-6,8,10,12-tetraenoic acid (LipoxinB4); LTB4: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid (Leukotriene B4); 3HMYR: 3-Hydroxy-tetradecanoic acid; 16HPAL: 16-Hydroxy-hexadecanoic acid; 12HEST: 12-Hydroxyoctadecanoic acid. PGF2α: (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl] hept-5-enoic acid (Prostaglandin 2α); IFC: intrahepatic fat content; MDA: malondialdehyde.