. 2023 Mar 13;12(3):711. doi: 10.3390/antiox12030711

Table 4.

Correlation between the circulating levels of free fatty acids and oxylipins.

		AA (nM)	EPA (nM)	ETA (nM)	15HETE (nM)	17HDoHE (nM)	RvD2 (nM)	MaR1 (nM)	LXB4 (nM)	LTB4 (nM)	3HMYR (nM)	16HPAL (nM)	12HEST (nM)
EPA (nM)	Cor	0.962 **	--
EPA (nM)	Sig	<0.001
ETA (nM)	Cor	0.963 **	0.930 **	--
ETA (nM)	Sig	<0.001	<0.001
15HETE (nM)	Cor	0.248 *	0.159	0.118	--
15HETE (nM)	Sig	0.015	0.124	0.254
17HDoHE (nM)	Cor	0.208 *	0.164	0.124	0.805 **	--
17HDoHE (nM)	Sig	0.043	0.113	0.232	<0.001
RvD2 (nM)	Cor	0.121	0.093	0.051	0.191	0.137	--
RvD2 (nM)	Sig	0.247	0.275	0.625	0.065	0.187
MaR1 (nM)	Cor	0.236 *	0.235 **	0.098	0.485 **	0.579 **	0.367 **	--
MaR1 (nM)	Sig	0.021	0.022	0.346	<0.001	<0.001	<0.001
LXB4 (nM)	Cor	0.161	0.148	0.018	0.365 **	0.350 **	0.387 **	0.903 **	--
LXB4 (nM)	Sig	0.119	0.153	0.864	<0.001	0.001	0.001	<0.001
LTB4 (nM)	Cor	0.161	0.193	0.013	0.090	0.507 **	0.107	0.347 **	0.310 **	--
LTB4 (nM)	Sig	0.119	0.061	0.904	0.319	<0.001	0.304	0.001	0.002
3HMYR (nM)	Cor	0.205 *	0.195	0.033	0.364 **	0.335 **	0.445 **	0.870 **	0.949 **	0.337 **	--
3HMYR (nM)	Sig	0.046	0.058	0.750	<0.001	0.001	<0.001	<0.001	<0.001	0.001
16HPAL (nM)	Cor	0.694 **	0.707 **	0.590 **	0.226 *	0.230 *	0.425 **	0.730 **	0.708 **	0.226 **	0.793 **	--
16HPAL (nM)	Sig	<0.001	<0.001	<0.001	0.028	0.025	<0.001	<0.001	<0.001	0.028	<0.001
12HEST (nM)	Cor	0.396 **	0.366 **	0.194	0.645 **	0.551 **	0.320 **	0.786 **	0.823 **	0.501 **	0.835 **	0.682 **	--
12HEST (nM)	Sig	<0.001	<0.001	0.060	<0.001	<0.001	0.002	<0.001	<0.001	<0.001	<0.001	<0.001
PGF2α (nM)	Cor	0.193	0.195	0.040	0.386 **	0.317 **	0.416 **	0.873 **	0.953 **	0.328 **	0.972 **	0.790 **	0.793 **
PGF2α (nM)	Sig	0.061	0.058	0.703	<0.001	0.002	<0.001	<0.001	<0.001	0.001	<0.001	<0.001	<0.001

Statistical analysis: Bivariate correlation Pearson test. Cor. indicates Pearson correlation coefficient. Sig. indicates statistical significance. Bold number indicates statistically significant ** p < 0.01 and * p < 0.05. AA: 5,8,11,14-Eicosatetraenoic acid (Arachidonic acid); EPA: 5,8,11,14,17-eicosapentenoic acid; ETA: 8,11,14,17-eicosatetraenoic acid; 15HETE: 15-Hydroxy-5,8,11,13-Eicosatetraenoic acid; 17DoHE: 17-Hydroxy-4,7,10,13,16,19-docosahexaenoic acid; RvD2: 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-docosahexaenoic acid (Resolvin D2); MaR1: 7R,14S-dihydroxy-4Z,8E,10E,12Z,16Z,19Z-docosahexaenoic acid (Maresin-1); LXB4: (5S,6E,8Z,10E,12E,14R,15S)-5,14,15-Trihydroxyicosa-6,8,10,12-tetraenoic acid (LipoxinB4); LTB4: (5S,6Z,8E,10E,12R,14Z)-5,12-Dihydroxyicosa-6,8,10,14-tetraenoic acid (Leukotriene B4); 3HMYR: 3-Hydroxy-tetradecanoic acid; 16HPAL: 16-Hydroxy-hexadecanoic acid; 12HEST: 12-Hydroxyoctadecanoic acid. PGF2α: (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid (Prostaglandin 2α).